Dr. Merav Setty

Implementation and application of computational methodologies for the design of new and improved bioactive compounds.
Exploring structural features in proteins responsible for ligands activity and specificity

 

Curriculum Vitae

Dr. Merav Setty (Fichman) is a lecturer at the Institute of Biochemistry, Food Science and Nutrition, at the Hebrew University, Israel.

Dr. Setty received a B.Sc in Chemistry (1990) and Master (1992) and PhD (Cum Laude, 1998) in Organic chemistry from the Hebrew University Jerusalem Israel.

Previously Dr. Setty acted as a Project Manager and Team Leader of Computational drug discovery at Epix pharmaceuticals, Israel. 
In 2000, as part of her interest in Computational Chemistry she graduated with honors from a Software Engineering Course for Academics at the College of Management.

List of Publications

Blum, JPI., M. Setty-Fichman S, L. Efron S, S. Shaik, RC. G. HarveyC. 1994. 
On the regioselectivity in transformation of benzo[a]pyrene 4,5-oxide and 3-methylcholanthrene 11,12-oxide to the corresponding β-amino-alcohol derivatives. 
Tetrahedron. 50(28): 8505-514. 2.160; 13/45; 2.

Setty-Fichman, M S., J. Blum PI, Y.Sasson PI, and M. Eisen C. 1994. 
Polystyrene-supported RhCl3-quaternary ammonium ion pair as a long-lived, efficient and recyclable catalyst. 
Tetra. Lett. 35(5): 781-84. 2.617; 9/45; 8.

Setty-Fichman, M PI., Y.Sasson and J. Blum. 1997. 
Double bond migration, cyclohexadiene disproportionation and alkyne hydration by Dowex®1-RhCl3 ion pair catalysts. 
J. Mol.Cat. 126(1):27-36. 1.657; 37/92; 10.

Setty-Fichman, M PI., K. Kupferman, V. Batz, C. Rottman Y.Sasson, and J. Blum. 1999. 
Dowex® 1-supported PtCl4 ion pair as a recycle hydrogenation catalyst. 
J. Mol. Cat. 144(1): 159-63. 1.744; 30/90; 0.

Becker, O. M., Y. Marantz, S. Shacham, B. Inbal, A. Heifetz, O. Kalid, S. Bar-Haim, D. Warshaviak, M. Fichman C, and S. Noiman. 2004. 
G protein-coupled receptors: in silico drug discovery in 3D. 
Proc Natl Acad Sci U S A 101(31):11304-9. 10.45; 3/45; 64.

Shacham, S., Y. Marantz, S. Bar-Haim, O. Kalid, D. Warshaviak, N. Avisar, B. Inbal, A. Heifetz, M. Fichman C, M. Topf, Z. Naor, S. Noiman, and O. M. Becker. 2004. 
PREDICT modeling and in-silico screening for G-protein coupled receptors. 
Proteins 57(1):51-86. 4.429; 52/261; 53.

Becker, O. M., D. S. Dhanoa, Y. Marantz, D. Chen, S. Shacham, S. Cheruku, A. Heifetz, P. Mohanty, M. Fichman C, A. Sharadendu, R. Nudelman, M. Kauffman, and S. Noiman. 2006. 
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. 
J Med Chem. 49(11):3116-35. 5.115; 4/35/ 41.

Sela, I., G. Golan, M. Strajbl, D. Rivenzon-Segal, S. Bar-Haim, I. Bloch, B. Inbal, A. Shitrit, E. Ben- Zeev, M. Fichman C, Y. Markus, Y. Marantz, H. Senderowitz and O. Kalid. 2010. 
G Protein Coupled Receptors - In Silico Drug Discovery and Design. 
Curr Top Med Chem. 10, 638-656. 4.473; 5/46; 1.