Prof. Oren Tirosh

Description of current research activities

Elucidation of cellular and molecular action of dietary antioxidants. Mitochondrial bioenergetics as a main organelle that regulates ROS (free radicals) production and role of antioxidants and oxidants in obesity and in liver diseases that involve ROS production.

Research projects

  1. Mechanisms underline hepatic ischemia reperfusion injury.
  2. Fat as a mediator in liver injury.


Curriculum Vitae

1987 - 1991: B.Sc. in Pharmacy, School of Pharmacy of the Hebrew University of Jerusalem.


1991 - 1992:


M.Sc. in Pharmaceutical Sciences, School of Pharmacy of the Hebrew University of Jerusalem.


1992 - 1997:


Ph.D. in Pharmaceutical Sciences (accelerated program) in the Departments of; Pharmaceutical Chemistry, Pharmaceutical Sciences, and Biochemistry of the Hebrew University of Jerusalem.


7/97 - 8/2000:


Post-doctorate fellow in the lab of professor Lester Packer, Department of Molecular and Cell Biology, University of California at Berkeley.


10/2000 - 3/2001:


Post-doctorate fellow in the Faculty of Medicine of the Hebrew University of Jerusalem.




Lecturer and a faculty member in the: Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem.




Senior lecturer.




Associate Professor of Nutritional Sciences.



Professional societies

  • Member of the Israeli Oxygen Society.
  • Member of the Oxygen Society (USA).




List of Publications

  • Shilo S., Aharoni-Simon M., Tirosh O. (2005) Selenium attenuates expression of MnSOD and uncoupling protein 2 in j774.2 macrophages: molecular mechanism for its cell-death and anti-inflammatory activity, Antioxid. Redox. Signal., 7(1&2): 276-286. 5.48;12/92; 5
  • Aronis A., Madar Z., Tirosh O. (2005) Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial ROS production and cellular necrosis, Free Rad. Biol. Med., 38(9):1221-1230. 4.81;18/82; 31
  • Zubare-Samuelov M., Shaul M.E. , Peri I, Aliluiko A, Tirosh O, Naim M. (2005) Inhibition of signal-termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste-signal termination, Am. J Physiol. Cell Physiol., 289(2):C483-492. 4.2; 9/78; 4
  • Ilan E., Tirosh O., Madar Z. (2005) Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes, J. Nutr., 135(9):2090-2095. 3.77; 7/56; 5
  • Tirosh O ., Pardo M., Schwartz B . , Miskin R. (2005) Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine, Mech. Ageing Dev. 126(12): 1262-1273, 4.3; 5/31; 8
  • Dasgupta J., Subbaram S., Connor K.M., Tirosh O., Melendez J.A. (2006) Manganese Superoxide Dismutase protects from TNF-α induced apoptosis by increasing the steady state production of H2O2Antioxid. Redox. Signal.8(7-8): 1295-1305, 7.58; 5/105; 22
  • Aharoni-Simon M., Reifen R., Tirosh O., (2006) ROS-Production-Mediated Activation of AP-1 but Not NFkB Inhibits Glutamate-Induced HT4 Neuronal Cell Death, Antioxid. Redox. Signal. 8(7-8): 1339-1349, 7.58;5/105;1
  • Abovich-gilad L., Tirosh O., Schwartz B., (2006) Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells, J. Endocrinol., 191(2): 387-398. 2.8;48/105; 12
  • Pardo M., Melendez J.A., Tirosh O. (2006) MnSOD Inactivation during Fas (CD95)-mediated apoptosis in Jurkat T cells, Free Rad. Biol. Med., 41(12): 1795-1806. 6.081;12/105; 8
  • Shilo S., Pardo M., Aharoni-Simon M. , Gliebter S., Tirosh O. (2008) Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection, J Inorg Biochem., 102(1):110-8. 3.25;9/44; 8
  • Tirosh O., Levy E. , Reifen R. (2007) High-selenium diet protects
    against TNBS-induced acute inflammation, mitochondrial dysfunction and secondary necrosis in rat colon, Nutrition, 23(11-12):878-86. 2.6;23/66; 11
  • Aronis A., Madar Z., Tirosh O. (2008) Lipotoxic effects of triacylglycerols in J774.2 macrophages, Nutrition. 24(2):167-76. 2.6;23/66; 9
  • Budick-harmelin N., Dudas J., Demuth J., Madar Z., Ramadori G. Tirosh O. (2008) triglycerides potentiate the inflammatory response in rat kupffer cells, Antioxid. Redox. Signal., 10(12):2009-22. 7.58;5/105;7
  • Tirosh O. , Ilan E. , Anavi S., Ramadori G., Madar Z. (2009) Nutritional lipids-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes, Nutrition, 25(2):200-8. 2.6;23/66, 2
  • Pardo M., Budick-harmelin N., Tirosh B., Tirosh O. (2008) Antioxidant defense in hepatic ischemia-reperfusion injury is regulated by damage-associated molecular pattern signal molecules, Free Rad. Biol. Med., 45(8):1073-83. 6.081;12/105;6
  • Tirosh O. , Ilan E. , Budick-harmelin N. , Ramadori G. , Madar Z. (2009) Down regulation of eNOS in a nutritional model of fatty liver, e-SPEN. 4(2);e101-e104. (1 citation)
  • Pardo M., Tirosh O., (2009) Protective signaling effect of Manganese superoxide dismutase in hypoxia-reoxygenation of hepatocytes, Free Radical Research, 43(12):1225-39. 2.25;176/283,3
  • Aronis A., Aharoni-Simon M., Madar Z., Tirosh O. (2009) Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch. Biochem. Biophys. 492(1-2):74-81. 2.63, 30/70, 3
  • Tirosh O. , Artan A., Aharoni-Simon M. , Ramadori, G. , Madar Z. (2010) Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase. Antioxid. Redox. Signal., 13(1):13-26. 7.58; 5/105; (appears on journal cover)
  • Anavi S. , Ilan E. , Tirosh O. , Madar Z. (2010) Infusion of a lipid emulsion modulates AMPK and related proteins in rat liver, muscle and adipose tissues. Obesity, 18(6):1108-15, 2.76,16/59, 2
  • Aharoni-Simon M., Hann-Obercyge M. , Pen S. ,Madar Z. , Tirosh O. (2011) Fatty Liver is Associated with Impaired Activity of PPAR gamma-Coactivator 1alpha; (PGC1alpha) and Mitochondrial Biogenesis in Mice, Laboratory Investigation, 91(7):1018-28, 4.6, 16/93


Peer reviewer (regular journals)

Antioxidants & Redox Signaling, Pharmacological Research

Diabetes, Obesity and Metabolism, Cellular and Molecular Life Sciences, The Journal of Biological Chemistry, BBA – Bioenergetics, Clinical Nutrition, FEBS Letters, Journal of Gene Medicine, Gene and Nutrition, Leukemia Research.



2011: Liver Injury and Immune Response: Non-alcoholic Fatty Liver Disease and Alcoholic Liver Disease [Paperback] Khem Bahadur Adhikari (Author), Oren Tirosh (Author), Lambert Academic publishing.

Chapters in books

  1. Aba Priev, Ayelet M. Samuni, Oren Tirosh and Yechezkel Barenholz. The role of hydration in stabilization of liposomes: resistance to oxidative damage of PEG-grafted liposome. In: "Targeting of Drugs 6: Strategies for Stealth Therapeutic Systems". G.Gregoriadis ed., Plenum Publishing Corporation, 1998.
  2. Oren Tirosh, Abraham Z.Reznick. Chemical bases and physiological relevance of protein oxidation. 
    In: "Handbook of Oxidants and Antioxidants in Exerci",C.K Sen, L. Packer, O. Hanninen eds., Elsevier Science B.V., Amsterdam, 89-115, 2000.
  3. Oren Tirosh, Sashwati Roy and Lester Packer, Lipoic Acid: cellular metabolism, antioxidant activity and clinical relevancy. In: "Handbook of Antioxidants", L. Packer, E. Cadanes eds., Marcel Dekker, Inc., 473-488 2002.
  4. Oren Tirosh, Shani Shilo, Anna Aronis and Chandan K. Sen, Redox Regulation of Mitochondrial Permeability Transition:Contrasting effects of Lipoic Acid and Its Positively Charged Analoge LA-plus, "Thiol Metabolism and Redox Regulation of Cellular Functions", A Pompella, G Banhegyi, MW Rousseau. Series I: life and Behavioral Sciences\Vol 347, 317-327. 2002.
  5. Oren Tirosh and Anna Aronis (2007) Lipid-induced death of macrophages: implication for destabilization of atherosclerotic plaques, "Oxidative Stress & Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome", L. Packer and H. Sies (Eds): Taylor and Francis Group, LLC Boca Raton, FL.
  6. Oren Tirosh (2011) Hypoglycemia, Invited book chapter based on article #48 (in press), Sepsis and hypoglycemia: the lipid connection, Intech Open access publisher. Hypoglycemia / Book 2", ISBN 979-953-307-245-5.



Approved Patents

  1. Oren Tirosh, Jehoshoua Katzhendler, Yechezkel Barenholz and Ron Kohen.
    Radiation-protective phospholipid and method.
    US patent no' 5817856, 6/10/98.
  2. Oren Tirosh, Chandan K. Sen, Sashwati Roy and Lester Packer.
    Lipoic acid analogs.
    U.S patent no' 6108570, 18/7/2000.
  3. Ron Kohen, David Fanberstine and Oren Tirosh.
    Device and method for quantitative determination of oxidants and/or
    antioxidants in the skin.
    US patent no' 6108570, 22/8/2000.
  4. Oren Tirosh, Jehoshoua Katzhendler, Yechezkel Barenholz,
    Isaac Ginsburg and Ron Kohen.
    Thionophosphate derivatives, process for theirpreparation and
    pharmaceutical compositions containing them.
    US patent no' 6200962 B1 13/5/2001.


1991:  The Hebrew University Rector Scholarship.
1992:     The Abraham Ziv award for excellent master degree research work.
1998:     The Hebrew University Alice Sussman fellowship.
1998: The Oxygen Club of California. Young researchers award.
2000: Lady Davis fellowship (The Hebrew University of Jerusalem).
2002:  Junior Investigator Award (Wound healing: oxygen and emerging therapies). For Scientific Merit of Submitted Abstract.