Table of Contents

Contact Us

Head of Institute: Prof. Oren Tirosh

Administrative manager: Ms. Yael Fruchter

Office Address:
Institute of Biochemistry, Food Science and Nutrition,
Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem, 
P.O.Box 12, Rehovot 7610001, ISRAEL

Tel: +972 - (0)8-9489385
Fax: +972 - (0)8-9363208
Email Address: yaelf@savion.huji.ac.il

List of Publications

  • Shilo S., Aharoni-Simon M., Tirosh O. (2005) Selenium attenuates expression of MnSOD and uncoupling protein 2 in j774.2 macrophages: molecular mechanism for its cell-death and anti-inflammatory activity, Antioxid. Redox. Signal., 7(1&2): 276-286. 5.48;12/92; 5
  • Aronis A., Madar Z., Tirosh O. (2005) Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial ROS production and cellular necrosis, Free Rad. Biol. Med., 38(9):1221-1230. 4.81;18/82; 31
  • Zubare-Samuelov M., Shaul M.E. , Peri I, Aliluiko A, Tirosh O, Naim M. (2005) Inhibition of signal-termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste-signal termination, Am. J Physiol. Cell Physiol., 289(2):C483-492. 4.2; 9/78; 4
  • Ilan E., Tirosh O., Madar Z. (2005) Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes, J. Nutr., 135(9):2090-2095. 3.77; 7/56; 5
  • Tirosh O ., Pardo M., Schwartz B . , Miskin R. (2005) Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine, Mech. Ageing Dev. 126(12): 1262-1273, 4.3; 5/31; 8
  • Dasgupta J., Subbaram S., Connor K.M., Tirosh O., Melendez J.A. (2006) Manganese Superoxide Dismutase protects from TNF-α induced apoptosis by increasing the steady state production of H2O2Antioxid. Redox. Signal.8(7-8): 1295-1305, 7.58; 5/105; 22
  • Aharoni-Simon M., Reifen R., Tirosh O., (2006) ROS-Production-Mediated Activation of AP-1 but Not NFkB Inhibits Glutamate-Induced HT4 Neuronal Cell Death, Antioxid. Redox. Signal. 8(7-8): 1339-1349, 7.58;5/105;1
  • Abovich-gilad L., Tirosh O., Schwartz B., (2006) Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells, J. Endocrinol., 191(2): 387-398. 2.8;48/105; 12
  • Pardo M., Melendez J.A., Tirosh O. (2006) MnSOD Inactivation during Fas (CD95)-mediated apoptosis in Jurkat T cells, Free Rad. Biol. Med., 41(12): 1795-1806. 6.081;12/105; 8
  • Shilo S., Pardo M., Aharoni-Simon M. , Gliebter S., Tirosh O. (2008) Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection, J Inorg Biochem., 102(1):110-8. 3.25;9/44; 8
  • Tirosh O., Levy E. , Reifen R. (2007) High-selenium diet protects
    against TNBS-induced acute inflammation, mitochondrial dysfunction and secondary necrosis in rat colon, Nutrition, 23(11-12):878-86. 2.6;23/66; 11
  • Aronis A., Madar Z., Tirosh O. (2008) Lipotoxic effects of triacylglycerols in J774.2 macrophages, Nutrition. 24(2):167-76. 2.6;23/66; 9
  • Budick-harmelin N., Dudas J., Demuth J., Madar Z., Ramadori G. Tirosh O. (2008) triglycerides potentiate the inflammatory response in rat kupffer cells, Antioxid. Redox. Signal., 10(12):2009-22. 7.58;5/105;7
  • Tirosh O. , Ilan E. , Anavi S., Ramadori G., Madar Z. (2009) Nutritional lipids-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes, Nutrition, 25(2):200-8. 2.6;23/66, 2
  • Pardo M., Budick-harmelin N., Tirosh B., Tirosh O. (2008) Antioxidant defense in hepatic ischemia-reperfusion injury is regulated by damage-associated molecular pattern signal molecules, Free Rad. Biol. Med., 45(8):1073-83. 6.081;12/105;6
  • Tirosh O. , Ilan E. , Budick-harmelin N. , Ramadori G. , Madar Z. (2009) Down regulation of eNOS in a nutritional model of fatty liver, e-SPEN. 4(2);e101-e104. (1 citation)
  • Pardo M., Tirosh O., (2009) Protective signaling effect of Manganese superoxide dismutase in hypoxia-reoxygenation of hepatocytes, Free Radical Research, 43(12):1225-39. 2.25;176/283,3
  • Aronis A., Aharoni-Simon M., Madar Z., Tirosh O. (2009) Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch. Biochem. Biophys. 492(1-2):74-81. 2.63, 30/70, 3
  • Tirosh O. , Artan A., Aharoni-Simon M. , Ramadori, G. , Madar Z. (2010) Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase. Antioxid. Redox. Signal., 13(1):13-26. 7.58; 5/105; (appears on journal cover)
  • Anavi S. , Ilan E. , Tirosh O. , Madar Z. (2010) Infusion of a lipid emulsion modulates AMPK and related proteins in rat liver, muscle and adipose tissues. Obesity, 18(6):1108-15, 2.76,16/59, 2
  • Aharoni-Simon M., Hann-Obercyge M. , Pen S. ,Madar Z. , Tirosh O. (2011) Fatty Liver is Associated with Impaired Activity of PPAR gamma-Coactivator 1alpha; (PGC1alpha) and Mitochondrial Biogenesis in Mice, Laboratory Investigation, 91(7):1018-28, 4.6, 16/93

 

Peer reviewer (regular journals)

Antioxidants & Redox Signaling, Pharmacological Research

Diabetes, Obesity and Metabolism, Cellular and Molecular Life Sciences, The Journal of Biological Chemistry, BBA – Bioenergetics, Clinical Nutrition, FEBS Letters, Journal of Gene Medicine, Gene and Nutrition, Leukemia Research.

 

Books

2011: Liver Injury and Immune Response: Non-alcoholic Fatty Liver Disease and Alcoholic Liver Disease [Paperback] Khem Bahadur Adhikari (Author), Oren Tirosh (Author), Lambert Academic publishing. http://www.amazon.com/Liver-Injury-Immune-Response-Non-alcoholic/dp/3844...

Chapters in books

  1. Aba Priev, Ayelet M. Samuni, Oren Tirosh and Yechezkel Barenholz. The role of hydration in stabilization of liposomes: resistance to oxidative damage of PEG-grafted liposome. In: "Targeting of Drugs 6: Strategies for Stealth Therapeutic Systems". G.Gregoriadis ed., Plenum Publishing Corporation, 1998.
  2. Oren Tirosh, Abraham Z.Reznick. Chemical bases and physiological relevance of protein oxidation. 
    In: "Handbook of Oxidants and Antioxidants in Exerci",C.K Sen, L. Packer, O. Hanninen eds., Elsevier Science B.V., Amsterdam, 89-115, 2000.
  3. Oren Tirosh, Sashwati Roy and Lester Packer, Lipoic Acid: cellular metabolism, antioxidant activity and clinical relevancy. In: "Handbook of Antioxidants", L. Packer, E. Cadanes eds., Marcel Dekker, Inc., 473-488 2002.
  4. Oren Tirosh, Shani Shilo, Anna Aronis and Chandan K. Sen, Redox Regulation of Mitochondrial Permeability Transition:Contrasting effects of Lipoic Acid and Its Positively Charged Analoge LA-plus, "Thiol Metabolism and Redox Regulation of Cellular Functions", A Pompella, G Banhegyi, MW Rousseau. Series I: life and Behavioral Sciences\Vol 347, 317-327. 2002.
  5. Oren Tirosh and Anna Aronis (2007) Lipid-induced death of macrophages: implication for destabilization of atherosclerotic plaques, "Oxidative Stress & Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome", L. Packer and H. Sies (Eds): Taylor and Francis Group, LLC Boca Raton, FL.
  6. Oren Tirosh (2011) Hypoglycemia, Invited book chapter based on article #48 (in press), Sepsis and hypoglycemia: the lipid connection, Intech Open access publisher. Hypoglycemia / Book 2", ISBN 979-953-307-245-5.