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Contact Us

Head of Institute: Prof. Oren Tirosh

Administrative manager: Rakefet Kalev

Office Address:
Institute of Biochemistry, Food Science and Nutrition,
Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem, 
Herzl 229, Rehovot 7610001, ISRAEL

Tel: +972 - (0)8-9489385
Fax: +972 - (0)8-9363208
Email Address:

List of Publications

  • Shilo S., Aharoni-Simon M., Tirosh O. (2005) Selenium attenuates expression of MnSOD and uncoupling protein 2 in j774.2 macrophages: molecular mechanism for its cell-death and anti-inflammatory activity, Antioxid. Redox. Signal., 7(1&2): 276-286. 5.48;12/92; 5
  • Aronis A., Madar Z., Tirosh O. (2005) Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial ROS production and cellular necrosis, Free Rad. Biol. Med., 38(9):1221-1230. 4.81;18/82; 31
  • Zubare-Samuelov M., Shaul M.E. , Peri I, Aliluiko A, Tirosh O, Naim M. (2005) Inhibition of signal-termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste-signal termination, Am. J Physiol. Cell Physiol., 289(2):C483-492. 4.2; 9/78; 4
  • Ilan E., Tirosh O., Madar Z. (2005) Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes, J. Nutr., 135(9):2090-2095. 3.77; 7/56; 5
  • Tirosh O ., Pardo M., Schwartz B . , Miskin R. (2005) Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine, Mech. Ageing Dev. 126(12): 1262-1273, 4.3; 5/31; 8
  • Dasgupta J., Subbaram S., Connor K.M., Tirosh O., Melendez J.A. (2006) Manganese Superoxide Dismutase protects from TNF-α induced apoptosis by increasing the steady state production of H2O2Antioxid. Redox. Signal.8(7-8): 1295-1305, 7.58; 5/105; 22
  • Aharoni-Simon M., Reifen R., Tirosh O., (2006) ROS-Production-Mediated Activation of AP-1 but Not NFkB Inhibits Glutamate-Induced HT4 Neuronal Cell Death, Antioxid. Redox. Signal. 8(7-8): 1339-1349, 7.58;5/105;1
  • Abovich-gilad L., Tirosh O., Schwartz B., (2006) Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells, J. Endocrinol., 191(2): 387-398. 2.8;48/105; 12
  • Pardo M., Melendez J.A., Tirosh O. (2006) MnSOD Inactivation during Fas (CD95)-mediated apoptosis in Jurkat T cells, Free Rad. Biol. Med., 41(12): 1795-1806. 6.081;12/105; 8
  • Shilo S., Pardo M., Aharoni-Simon M. , Gliebter S., Tirosh O. (2008) Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection, J Inorg Biochem., 102(1):110-8. 3.25;9/44; 8
  • Tirosh O., Levy E. , Reifen R. (2007) High-selenium diet protects
    against TNBS-induced acute inflammation, mitochondrial dysfunction and secondary necrosis in rat colon, Nutrition, 23(11-12):878-86. 2.6;23/66; 11
  • Aronis A., Madar Z., Tirosh O. (2008) Lipotoxic effects of triacylglycerols in J774.2 macrophages, Nutrition. 24(2):167-76. 2.6;23/66; 9
  • Budick-harmelin N., Dudas J., Demuth J., Madar Z., Ramadori G. Tirosh O. (2008) triglycerides potentiate the inflammatory response in rat kupffer cells, Antioxid. Redox. Signal., 10(12):2009-22. 7.58;5/105;7
  • Tirosh O. , Ilan E. , Anavi S., Ramadori G., Madar Z. (2009) Nutritional lipids-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes, Nutrition, 25(2):200-8. 2.6;23/66, 2
  • Pardo M., Budick-harmelin N., Tirosh B., Tirosh O. (2008) Antioxidant defense in hepatic ischemia-reperfusion injury is regulated by damage-associated molecular pattern signal molecules, Free Rad. Biol. Med., 45(8):1073-83. 6.081;12/105;6
  • Tirosh O. , Ilan E. , Budick-harmelin N. , Ramadori G. , Madar Z. (2009) Down regulation of eNOS in a nutritional model of fatty liver, e-SPEN. 4(2);e101-e104. (1 citation)
  • Pardo M., Tirosh O., (2009) Protective signaling effect of Manganese superoxide dismutase in hypoxia-reoxygenation of hepatocytes, Free Radical Research, 43(12):1225-39. 2.25;176/283,3
  • Aronis A., Aharoni-Simon M., Madar Z., Tirosh O. (2009) Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch. Biochem. Biophys. 492(1-2):74-81. 2.63, 30/70, 3
  • Tirosh O. , Artan A., Aharoni-Simon M. , Ramadori, G. , Madar Z. (2010) Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase. Antioxid. Redox. Signal., 13(1):13-26. 7.58; 5/105; (appears on journal cover)
  • Anavi S. , Ilan E. , Tirosh O. , Madar Z. (2010) Infusion of a lipid emulsion modulates AMPK and related proteins in rat liver, muscle and adipose tissues. Obesity, 18(6):1108-15, 2.76,16/59, 2
  • Aharoni-Simon M., Hann-Obercyge M. , Pen S. ,Madar Z. , Tirosh O. (2011) Fatty Liver is Associated with Impaired Activity of PPAR gamma-Coactivator 1alpha; (PGC1alpha) and Mitochondrial Biogenesis in Mice, Laboratory Investigation, 91(7):1018-28, 4.6, 16/93


Peer reviewer (regular journals)

Antioxidants & Redox Signaling, Pharmacological Research

Diabetes, Obesity and Metabolism, Cellular and Molecular Life Sciences, The Journal of Biological Chemistry, BBA – Bioenergetics, Clinical Nutrition, FEBS Letters, Journal of Gene Medicine, Gene and Nutrition, Leukemia Research.



2011: Liver Injury and Immune Response: Non-alcoholic Fatty Liver Disease and Alcoholic Liver Disease [Paperback] Khem Bahadur Adhikari (Author), Oren Tirosh (Author), Lambert Academic publishing.

Chapters in books

  1. Aba Priev, Ayelet M. Samuni, Oren Tirosh and Yechezkel Barenholz. The role of hydration in stabilization of liposomes: resistance to oxidative damage of PEG-grafted liposome. In: "Targeting of Drugs 6: Strategies for Stealth Therapeutic Systems". G.Gregoriadis ed., Plenum Publishing Corporation, 1998.
  2. Oren Tirosh, Abraham Z.Reznick. Chemical bases and physiological relevance of protein oxidation. 
    In: "Handbook of Oxidants and Antioxidants in Exerci",C.K Sen, L. Packer, O. Hanninen eds., Elsevier Science B.V., Amsterdam, 89-115, 2000.
  3. Oren Tirosh, Sashwati Roy and Lester Packer, Lipoic Acid: cellular metabolism, antioxidant activity and clinical relevancy. In: "Handbook of Antioxidants", L. Packer, E. Cadanes eds., Marcel Dekker, Inc., 473-488 2002.
  4. Oren Tirosh, Shani Shilo, Anna Aronis and Chandan K. Sen, Redox Regulation of Mitochondrial Permeability Transition:Contrasting effects of Lipoic Acid and Its Positively Charged Analoge LA-plus, "Thiol Metabolism and Redox Regulation of Cellular Functions", A Pompella, G Banhegyi, MW Rousseau. Series I: life and Behavioral Sciences\Vol 347, 317-327. 2002.
  5. Oren Tirosh and Anna Aronis (2007) Lipid-induced death of macrophages: implication for destabilization of atherosclerotic plaques, "Oxidative Stress & Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome", L. Packer and H. Sies (Eds): Taylor and Francis Group, LLC Boca Raton, FL.
  6. Oren Tirosh (2011) Hypoglycemia, Invited book chapter based on article #48 (in press), Sepsis and hypoglycemia: the lipid connection, Intech Open access publisher. Hypoglycemia / Book 2", ISBN 979-953-307-245-5.