Table of Contents

Contact Us

Head of Institute: Prof. Oren Tirosh

Administrative manager: Ms. Yael Fruchter

Office Address:
Institute of Biochemistry, Food Science and Nutrition,
Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem, 
P.O.Box 12, Rehovot 7610001, ISRAEL

Tel: +972 - (0)8-9489385
Fax: +972 - (0)8-9363208
Email Address:

List of Publications

Peer-Reviewed Publications


  • Amso Z, Hayouka Z. Antimicrobial random peptide cocktails: a new approach to fight pathogenic bacteria. Chem Commun (Camb). 2019; 55, 2007-2014. (Invited Review- Featured article).
  • Yehuda A, Slamti L, Malach E, Lereclus D and Hayouka Z. Elucidating the Hot Spot Residues of Quorum Sensing Peptidic Autoinducer PapR by Multiple Amino Acids Replacements, Frontiers Microbiology, 2019; 10, 1246.
  • Tal Stern Bauer, Barak Menagen, David Avnir and Zvi Hayouka. Random peptide mixtures entrapped within a copper-cuprite matrix: new antimicrobial agent against methicillin-resistant Staphylococcus aureus. Scientific reports. 9(1):11215
  • Vinayak Ghate⁠a⁠, Einat Zelinger⁠, Hagit Shoyhet⁠, Zvi Hayouka. Inactivation of Listeria monocytogenes on paperboard, a food packaging material, using 410nm light emitting diodes. Food control, 2019, 96, 281-290.


  • Carla Vilela, Mia Kurek, Zvi Hayouka, Bettina Rocker, Selçuk Yildirim, Maria Dulce Antunes, Julie Nilsen-Nygaard, Marit Pettersen, Carmen Freire. A concise guide to active agents for active food packaging. Trends in Food Science & Technology, 2018, 80, 212-222 (Review).
  • Yehuda A, Slamti L, Bochnik-Tamir R, Malach E, Lereclus D and Hayouka Z. Turning off Bacillus cereus quorum sensing system with peptidic analogs. Chemical Communication, 2018, 54, 9777-9780.
  • Ocłoń E, Solomon G, Hayouka Z, Gertler A. Preparation of biologically active monomeric recombinant zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss) recombinant growth hormones. Fish Physiology and Biochemistry, 2018, 44, 1215-1222.
  • Stern T and Hayouka Z. Identification and eradication of pasteurized bovine milk associated bacteria using random antimicrobial peptide mixtures. Journal of Peptide Science, 2018, e3088 .
  • Topman S, Bochnick Tamir H, Burdman S and Hayouka Z. Random peptide mixture as crop protection agents. Microbial biotechnology, 2018. ‏
  • Hu S, Zhao Y, Hayouka Z, Wang D, Jiao S. Inactivation kinetics for Salmonella typhimurium in red pepper powders treated by radio frequency heating (2018). Food controlIn press.
  • Oclon, E, Solomon G, Hayouka Z, Salame T, Goffin V, Gertler A. Novel reagents for human prolactin research: large-scale preparation and characterization of prolactin receptor extracellular domain, non-pegylated and pegylated prolactin and prolactin receptor antagonist. Protein Engineering, Design, and Selection. In press.


  • Hayouka Z*, Bella A, Stern T, Ray S, Jiang H, Grovenor CRM, Ryadnov MG. Binary Encoding of Random Peptide Sequences for Selective and Differential Antimicrobial Mechanisms. Angew Chem Int Ed Engl. 2017 . doi:10.1002/anie.201702313
    * corresponding author


  • Stern T, Zelinger E, Hayouka Z. Random peptide mixtures inhibit and eradicate methicillin-resistant Staphylococcus aureus biofilms.Chem Commun (Camb). 2016 Jun 4;52(44):7102-5.


  • Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, Gellman SH. Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif. J Am Chem Soc. 2015 Sep 23;137(37):11884-7.


  • Ilona Patursky-Polischuk, Judith Kasir, Rachel Miloslavski, Hayouka Z, Mirit Hausner-Hanochi, Miri Stolovich-Rain, Pinchas Tsukerman, Moshe Biton, Rajini Mudhasani, Stephen N. Jones and Oded Meyuhas. PLOS ONE 2014. Oct 22;9(10)
  • Chakraborty, Saswata; Liu, Runhui; Hayouka, Z; Chen, Xinyu; Ehrhardt, Jeffrey; Lu, Qin; Burke, Eileen; Yang, Yiqing; Weisblum, Bernard; Wong, Gerard; Masters, Kristyn; Gellman, Samuel. Ternary Nylon-3 Copolymers as Host-Defense Peptide Mimics:  Beyond Hydrophobic and Cationic Subunits. J. Am. Chem. Soc. 2014 Oct 15;136(41)
  • Liu R, Chen X, Chakraborty S, Lemke JJ, Hayouka Z, Chow C, Welch RA, Weisblum B, Masters KS, Gellman SH. Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern. J. Am. Chem. Soc. 2014  Mar 19;136(11):4410-8
  • Miloslavski R, Cohen E, Avraham A, Iluz Y, Hayouka Z, Kasir J, Mudhasani R, Jones SN, Cybulski N, Rüegg MA, Larsson O, Gandin V, Rajakumar A, Topisirovic I, Meyuhas O. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J Mol Cell Biol. 2014. Jun;6(3):255-66.


  • Hayouka Z, David E. Mortenson, Dale F. Kreitler, Bernard Weisblumb, Katrina T. Forestc, Samuel H. Gellmana. Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-Ray Crystal Structure of a Magainin 2 Derivative. J. Am. Chem. Soc. 2013. Oct 23;135(42):15738-41
  • Hayouka Z, Chakraborty S, Liu R, Samuel H. Gellman. Interplay Among Subunit Identity, Composition, Chain Length and Stereochemistry in the Activity Profile of Sequence-Random Oligomer Mixtures. J. Am. Chem. Soc. 2013 Aug 14;135(32):11748-51
  • Chakraborty S, Liu R, Hayouka Z, Samuel H. Gellman. Studying the effect of cyclic versus acyclic nylon-3 polymers. ACS macro letter, 2013
  • Liu R, Chen X, Hayouka Z, Chakraborty S, Falk SP, Weisblum B, Masters KS, Gellman SH. Nylon-3 polymers with selective antifungal activity.J Am Chem Soc. 2013 Apr 10;135(14):5270-3
  • Liu R, Chakraborty S, Hayouka Z, Samuel H. Gellman. Nylon-3 polymer as antifungal agent.  J. Am. Chem. Soc. 2013, 135, 5270-3.

Older publications:

  • Hayouka Zvi, A. Levin, M. Hurevich, D. E. Shalev, A. Loyter, C. Gilon, A. Friedler. Backbone versus side chain to side chain cyclization of LEDGF 361-370 as an anti HIV-1 lead compound. Bioorg Med Chem. 2012, 20, 3317-22.
  • Helman A, Cinnamon E, Mezuman S, Hayouka Zvi, Von Ohlen T, Orian A, Jiménez G, Paroush Z. Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. Current Biology. 2011, 21, 1102-1110.
  • Levin, H. Benyamini,  HayoukaZvi, A. Friedler, A. Loyter. Peptides that bind the HIV-1 integrase and modulate its enzymatic activity: Kinetic studies and mode of action. FEBS,2011 Jan;278(2):316-30.
  • Levin A, Hayouka Zvi, Friedler A, Loyter A. Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus.1(5) :422-431, 2010.
  • Levin A, Hayouka Zvi, Friedler A, Loyter A. Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein. Nucleus. 1(2):190-201, 2010.
  • Hayouka Zvi., Levin, A., Loyter, A., and Friedler, A. Peptide inhibitors of the HIV-1 integrase protein. Bulletin of the Israel Chemical Society 25, 20-28, 2010.
  • Hayouka Zvi, M. Hurevich, A. Levin, M. Maes, D. E. Shalev, A. Loyter, C. Gilon, A. Friedler. Conformational cyclic peptide libraries: mimicking the bioactive conformation of LEDGF/p75 and inhibiting HIV-1 integrase. Bioorganic and Medicinal Chemistry.  18(23):8388-95 (2010).
  • Levin A, Hayouka Zvi, Helfer M, Brack-Werner R, Friedler A, Loyter A. Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein. Biopolymers, 93(8): 740-51, 2010.  
  • Garty S, Kimelman-Bleich N, Hayouka Zvi, Cohn D, Friedler A, Pelled G, Gazit D. Peptide-modified "smart" hydrogels and genetically engineered stem cells for skeletal tissue engineering. Biomacromolecules. 11(6):1516-26, 2010.
  • Levin A, Hayouka Zvi, Friedler A, Loyter A Specific eradication of HIV-1 from infected cultured cells. AIDS Res Ther. (7):31, 2010.
  • Levin A, Hayouka Zvi, Friedler A, Loyter A. Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells. J. Virol. (7) :177, 2010.
  • Levin A, Hayouka Zvi, Friedler A, Loyter A. Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells. Virus Genes. 2010 Jun;40(3):341-6. .
  • Hayouka Zvi, Aviad Levin, Michal Maes, Eran Hadas, Deborah E. Shalev, David J. Volsky, Abraham Loyter and Assaf Friedler. Mechanism of action of the HIV-1 Integrase Inhibitory Peptide LEDGF 361-370. Biochem Biophys Res Commun. 394(2): 260-5, 2010.
  • Levin A, Rosenbluh J, Zvi Hayouka, Friedler A, Loyter A. Integration of HIV-1 DNA is regulated by interplay between viral Rev and cellular LEDGF/p75 proteins. Mol Med. 2010 Jan-Feb;16(1-2):34-44
  •  Levin A, Hayouka Zvi, Brack-Werner R, Volsky DJ, Friedler A, Loyter A. Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. Protein Eng Des Sel.  (12):753-63, 2009.
  •  Aviad Levin, Zvi Hayouka, Ruth Brack-Werner, David J. Volsky, Assaf Friedler and Abraham Loyter. A novel function of HIV-1 Rev limits integration and extends cells survival. Protein Eng Des Sel. 22(12):753-63, 2009.
  • Michal Maes, Aviad Levin, Zvi Hayouka, Abraham Loyter, Assaf Friedler. Peptide inhibitors of HIV-1 integrase: from mechanistic studies to development of improved leads. Bioorg Med Chem. 17(22): 7635-42, 2009.
  • Aviad Levin, Zvi Hayouka, Markus Helfer, Ruth Brack-Werner, Assaf Friedler and Abraham Loyter.  Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. PLoS ONE, 4(1): e4155, 2009.
  • Ronen Gabizon, Michal Mor, Masha M. Rosenberg, Lena Britan, Zvi Hayouka, Moshe Kotler, Deborah E. Shalev and Assaf Friedler. Using Peptides to Study the Interaction between the p53 Tetramerization Domain and HIV-1 Tat. Biopolymers: Peptide science, 90(2): 105-116, 2007.
  • Hayouka Zvi, Joseph Rosenbluh, Aviad Levin, Abraham Loyter & Assaf Friedler. Peptides derived from HIV-1 Rev inhibit HIV-1 Integrase in a shiftide mechanism. Biopolymers: Peptide science, 90(4):481-7, 2008. 
  • Ayelet Armon-Omer, Aviad Levin, Hayouka Zvi, Karin Butz, Felix Hoppe-Seyler, Shoshana Loya, Amnon Hizi, Assaf Friedler and Abraham Loyter. Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library. Journal of Molecular Biology, 376:  971-982, 2007.
  • Coster G, Hayouka Zvi, Argaman L, Friedler A, Brandeis M and Goldberg M. Linking the DNA damage response and cell cycle regulation: MDC1 directly interacts with the APC/C;  J. Biol. Chem., 288: 32053-64, 2007.
  • Kirshenboim N, Hayouka Zvi, Friedler A, Hizi A. Expression and characterization of a novel reverse transcriptase from the LTR retrotransposon Tf1; Virology, 366(2): 263-276,  2007.
  • Rosenbluh J, Hayouka Zvi, Loya S, Levin A, Armon-Omer A, Britan L, Hizi A, Kotler M, Friedler A and Loyter A. An interaction between the HIV-1 Rev and IN proteins: a base for the development of anti-HIV peptides, J Biol Chem; 282(21):15743-53, 2007.
  • Hayouka Zvi, Rosenbluh J, Levin A, Loya S, Lebendiker M, Veprintsev DB, Kotler M, Hizi A, Loyter A and  Friedler A. Inhibiting HIV-1 Integrase by Shifting its Oligomerization Equilibrium; Proc Natl Acad Sci U S A. 104(20): 8316-21, 2007.