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Contact Us

Head of Institute: Prof. Oren Tirosh

Administrative manager: Ms. Yael Fruchter

Office Address:
Institute of Biochemistry, Food Science and Nutrition,
Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem, 
P.O.Box 12, Rehovot 7610001, ISRAEL

Tel: +972 - (0)8-9489385
Fax: +972 - (0)8-9363208
Email Address:

List of Publications

  1. Zaretsky J, Griess-Fishheimer S, Carmi A, Travinsky Shmul T, Ofer L, Sinai T, Penn S, Shahar R, Monsonego-Ornan E. (2021) Ultra-processed food targets bone quality via endochondral ossification. Bone research 9 (1), 1-13
  2. Kalev-Altman R, Hanael E, Zelinger E, Blum M, Monsonego-Ornan E, Sela-Donenfeld D . (2020) Conserved role of matrix metalloproteases 2 and 9 in promoting the migration of neural crest cells in avian and mammalian embryos. FASEB J. 34(4):5240-5261.
  3. Antunes BP, Vainieri ML, Alini M, Monsonego-Ornan E, Grad S, Yayon A. (2020) Enhanced chondrogenic phenotype of primary bovine articular chondrocytes in Fibrin-Hyaluronan hydrogel by multi-axial mechanical loading and FGF18. Acta Biomater.105:170-179.
  4. Rozner R, Vernikov J, Griess-Fishheimer S, Travinsky T, Penn S, Schwartz B, Mesilati-Stahy R, Argov-Argaman N, Shahar R, Monsonego-Ornan E. (2020) The Role of Omega-3 Polyunsaturated Fatty Acids from Different Sources in Bone Development. Nutrients. 12(11):3494.
  5. Ofir O, Buch A, Rouach V, Goldsmith R, Stern N, Monsonego-Ornan E. (2020) Association between abdominal obesity and fragility fractures among elderly Israeli women. Aging Clin Exp Res. 32(8):1459-1467.
  6. Sinai T, Goldberg MR, Nachshon L, Amitzur-Levy R, Yichie T, Katz Y, Monsonego-Ornan E, Elizur A.J. (2019) Reduced Final Height and Inadequate Nutritional Intake in Cow's Milk-Allergic Young Adults. Allergy Clin Immunol Pract. 7(2):509-515.
  7. Ofer L, Dean MN, Zaslansky P,  Kult S, Shwartz Y, Zaretsky J, Griess-Fishheimer S, Monsonego-Ornan E, Zelzer E, Shahar R. (2019) A novel nonosteocytic regulatory mechanism of bone modeling. PLoS Biol. ;17(2):e3000140.
  8. Roth L, Kalev-Altman R, Monsonego-Ornan E, Sela-Donenfeld D. (2017) A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration. Int J Dev Biol. 61(3-4-5):245-256.
  9. Kalish‐Achrai N, MonsonegoOrnan E, Shahar R. (2017) Structure, composition, mechanics and growth of spines of the dorsal fin of blue tilapia Oreochromis aureus and common carp Cyprinus carpio. Journal of fish biology 90 (5), 2073-2096.
  10. Rub G, Marderfeld L, Poraz I, Hartman C, Amsel S, Rosenbaum I, Pergamentzev-Karpol S, Monsonego-Ornan E, Shamir RJ. (2016) Validation of a Nutritional Screening Tool for Ambulatory Use in Pediatrics. Pediatr Gastroenterol Nutr. 62(5):771-5.
  11. Dean MN, Ekstrom L, Monsonego-Ornan E, Ballantyne J, Witten PE, Riley C, Habraken W, Omelon S. (2015) Mineral homeostasis and regulation of mineralization processes in the skeletons of sharks, rays and relatives (Elasmobranchii). Semin Cell Dev Biol. 46:51-67.
  12. Solomon G, Atkins A, Shahar R, Gertler A, Monsonego-Ornan E. (2014) Effect of peripherally administered leptin antagonist on whole body metabolism and bone microarchitecture and biomechanical properties in the mouse. Am J Physiol Endocrinol Metab. 306:E14-27.
  13. Koren N, Simsa-Maziel S, Ron Shahar R, Schwartz B, and Monsonego-Ornan E. (2014). Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality. J Nutri Biochem. 25:623-33.
  14. Schminke, B. Muhammad, H. Bode, C. Boguslawa, S. Gerstdorf, N. Buergers, R. Monsonego Ornan, E Rosen, V. and Miosge, N. (2014). A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. Cell Mol Life Sci.7:1081-96.
  15. Rais Y, Reich A, Simsa-Maziel S, Moshe M, Idelevich A, Kfir T, Miosge N, Monsonego-Ornan E. (2014) The growth plate's response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium. Cell Mol Life Sci.
  16. Pando R, Masarwi M, Shtaif B, Idelevich A, Monsonego-Ornan E, Shahar R, Phillip M, Gat-Yablonski G. (2014) Bone quality is affected by food restriction and by nutrition-induced catch up growth. J Endocrinol. JOE-14-0486.
  17. Simsa-Maziel S, Reich A, Koren Y, Shahar R. and Monsonego Ornan E. (2013) L1-RI participates in normal growth plate development and bone modeling. Am J Physiol-Endoc M. 305(1):E15-21.
  18. Simsa-Maziel S, Sela-Donenfeld D. and Monsonego Ornan E. (2013) Matrix metalloproteinases in bone health and disease. Proteases in Cellular Dysfunctions, Springer.
  19. Bar A, Shoval I, Monsonego Ornan E and Sela-Donenfeld. (2013) The Role of Proteases in Embryonic Neural Crest Cells. Proteases in Cellular Dysfunctions, Springer.
  20. Simsa-Maziel, S. and Monsonego Ornan, E. (2012) Interleukin-1β promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21. Endocrinology. 153:2296-310.
  21. Monsonego Ornan, E.  Kosonovsky, J. Bar, A. Roth, L. Renki-Fragis, V. Simsa-Maziel, S. Kohl A. and Sela-Donenfeld, D. (2012) Matrix Metalloproteinase 9/Gelatinase B is Required for Neural Crest Cell Migration. Dev Biol. 364:162-77.
  22. Cohen L, Dean M, Shipov A, Atkins A, Monsonego-Ornan E. and Shahar R. (2012) Comparison of structural, architectural and mechanical aspects of cellular and acellular bone in two teleost fish. J Exp Biol. 215:1983-93.
  23. Amosi N, Zarhitsky S, Salnikov O, Monsonego-Ornan E, Shahar R. and Rapaport, H (2012) Acidic peptide hydrogels loaded with β-TCP particles act synergistically to induce bone regeneration. Acta Biomaterialia.8:2466-75.
  24.  Simsa-Maziel, S, Reich, A, Sela-Donenfeld, D. and Monsonego Ornan E. (2012). The role of Matrix Gla Protein in ossification and recovery of the avian growth plate. Frontiers in Bone Research; in Frontiers in Endocrinology.3:79. Dan, H,
  25. Muhammad, H. Rais, Y. Miosge, N. and Monsonego Ornan, E. (2012) The primary cilium as a dual sensor of mechanochemical signals in chondrocytes. Cellular and Molecular Life Sciences. 69(13):2101-7.
  26. Weisinger, K., Kohl, A., Kayam, G., Monsonego-Ornan, E and Sela-Donenfeld, D. (2011) Expression of hindbrain boundary markers is regulated by FGF3. Biology Open.  1:67-74.
  27. Bar-El Dadon S., Shahar, R., Katalan V., Monsonego-Ornan, E. And Reifen R. (2011) Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: Preliminary study. Nutrition. 27:973-7.
  28. Idelevich, A, Kerschnitzki, M, Shahar, R. and Monsonego-Ornan, E. (2011) 1,25(OH)2D3 alters growth plate maturation and bone architecture in young rats with normal renal function. PlosOne. 6, e20772.
  29. Sharir A, Israeli D, Milgram J., Monsonego-Ornan E., Currey JD. and Shahar R. (2011) The canine baculum: the structure and mechanical properties of an unusual bone. J Structural Biol. 175: 451.
  30. Idelevich, A., Rais, Y. and Monsonego-Ornan, E. (2011) Bone Gla Protein increases HIF-1α-dependent glucose metabolism and induces cartilage and vascular calcification. Arterioscler. Thromb. Vasc. Biol. 31:e55-71.
  31. Reich, A., Simsa-Maziel, S., Ashkenazi, Z. and Monsonego Ornan E (2010) Involvement of matrix metalloproteinases in the growth plate response to physiological mechanical load. J Appl Physiol. 108(1):172-80.
  32. Delessa Challa, T, Rais, Y and Monsonego Ornan, E (2010) Effect of Adiponectin on ATDC5 Proliferation, Differentiation and Signaling Pathways. Mol Cell Endocrinol. 323:282-91.
  33. Dan, H.,  Simsa-Maziel, S., Hasdai, A., Sela-Donenfeld, D. and Monsonego Ornan E. (2009) Expression of matrix metalloproteinases during impairment and recovery of the avian growth plate. J Anim Sci.87:3544-55.
  34. Shipov, A, Sharir, A, Zelzer, E, Milgram, J, Monsonego Ornan, E. and Shahar, R. (2009) The influence of severe and prolonged exercise restriction on the mechanical and structural properties of bone: an avian model. Vet J. 18, 153-160.
  35. Reich A., Sharir A., N., Zelzer E., O., Hacker L., Monsonego Ornan E. and Shahar R. (2008) The effect of weight loading and subsequent unloading on the post natal skeleton. Bone. 43:766-74.
  36. Negev-Hasky M., Simsa S., Tong A., Genina O. and Monsonego Ornan E. (2008)Involvement of the matrix metalloproteinases in vascularization and ossification of normal and impaired avian growth plate. J Anim Sci.86:1306-15.
  37. Monsonego Ornan E, and Ben-Ami M. (2008) The role of leptin in bone development and growth. Landes Bioscience. Leptin and Leptin Antagonists. 83-90.
  38. Krauss, S., Monsonego Ornan, E., Zelzer, E., Fratzl, P. and Shahar, R. (2008) Mechanical function of a complex three-dimensional suture joining the bony elements in the shell of the red-eared slider turtle. Advanced Material. 21, 407–412.  
  39. Simsa, S. and Monsonego Ornan, E. (2007) Endochondral Ossification Process of the Turkey (Meleagris gallopavo) During Embryonic and Juvenile Development. Poult Sci. 86:565.
  40. Simsa S, Hasdai A, Dan H and Monsonego Ornan E.(2007) Differential regulation of MMPs and matrix assembly in chicken and turkey growth-plate chondrocytes. Am J Physiol Regul Integr Comp Physiol; 29:2216-24.
  41. Simsa S, Genina O, Monsonego Ornan E. (2007) Matrix Metalloproteinase expression and localization in turkey (Meleagris gallopavo) during the endochondral ossification process. J Anim Sci.;85:1393-401.
  42. Simsa, S., Hasdai, A., Dan, H. and Monsonego Ornan, E. (2007) Induction of Tibial Dyschondroplasia in Turkeys by Tetramethylthiuram Disulphide (Thiram). Poult Sci.86:1766-71.
  43. Leach Jr. RM. and Monsonego Ornan E. (2007). Tibial dyschondroplasia – tools, new insights and future prospects World Poul. Sci. 86:2053-58.
  44. Ben-Zvi T, Yayon A, Gertler A and Monsonego Ornan E (2006). Suppressors of cytokine signaling (SOCS) 1 and 3 interact with and modulate fibroblast growth factor receptor signaling. J Cell Sci. 119:380-7.
  45. Reich A, Jaffe N, Genina O, Lavelin I, Nussinovitch A and Monsonego Ornan E (2005) Weight loading on young chicks inhibits bone elongation and promotes growth plate ossification and vascularization. J app Physiol. 98:2381-9.
  46. Weitzman S, Tong A, Reich A, Genina O, Yayon A and Monsonego Ornan E (2005). FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: Implications for endochondral ossification. Matrix Biol 24:520-9.
  47. Tong A, Reich A, Genin O, Pines M and Monsonego Ornan E (2003) The expression pattern of chicken 75-kDa gelatinase B-like enzyme in chondrocytes: evidence for its role in vascularization of the growth plate. J Bone Miner Res 18:1443-52.
  48. Rozenblatt-Rosen O., Monsonego Ornan E., Sadot E., Madar-Shapiro L., Sheinin Y., Ginsberg D. and Yayon A. (2002) Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations. J Cell Science 115; 553-62.
  49. Monsonego Ornan E, Adar R, Rom E and Yayon A (2002) Ligand-mediated ubiquitylation of wild type and mutant FGF receptors: dependence on tyrosine kinase activity and role in downregulation. Febs Letters. 528:83-9.
  50. Eswarakumar V.P., Monsonego Ornan E., Pines M., Antonopoulou I., Gillian M., Morriss-Kay and Lonai P. (2002) The IIIc alternative of Fgfr2 is a positive regulator of endochondral ossification. Development. 129: 3783-93.
  51. Adar. R., Monsonego Ornan E. and Yayon A. (2002) Effects of cysteine mutations in fibroblast growth factor receptor 3 on receptor dimerization and activation. J.Bone.Miner.Res 17: 860-8.
  52. Monsonego Ornan E, Adar R, Feferman T, Segev O and Yayon A (2000) The Achondroplasia mutation G380R in FGFR3 uncouples receptor activation from internalization. Mol Cell Biol 2; 516-22.
  53. Chen L., Adar R., Yang X., Monsonego Ornan E., Li C., Yayon A. and Deng C. (1999) An Achondroplasia type mutation (G369C) in murine FGFR3 retards long bone growth by inhibiting both chondrogenesis and osteogenesis. J. Clinical Invest. 104: 1517-25.
  54. Monsonego, E., Baumbach, W, Lavelin, I., Gertler, A, Hurwitz, S., and Pines, M. (1997). Generation of growth hormone binding protein by avian growth plate chondrocytes is dependent on cell differentiation. Mol Cell Endocrinol 135, 1-10.
  55. Pines, M., Monsonego, E., Knopov.V., Shalom-Barak, T, Halevy, O., and Hurwitz, S. (1995). The involvement of the epiphyseal growth-plate in longitudinal bone growth and in tibial dyschondroplasia. Archiv Fur Geflugelkunde. 28-30.
  56. Monsonego, E., Halevy, O., Gertler, A., Hurwitz, S., and Pines, M. (1995). Growth hormone inhibits differentiation of avian epiphyseal growth- plate chondrocytes Mol Cell Endocrinol 114, 35-42.
  57. Halevy, O., Monsonego, E., Marcelle, C., Hodik, V., Mett, A., and Pines, M. (1994). A new avian fibroblast growth factor receptor in myogenic and chondrogenic cell differentiation. Exp Cell Res 212, 278-84.
  58. Monsonego, E., Halevy, O., Gertler, A., Volokita, M., Schickler, M., Hurwitz, S., and Pines, M. (1993). Growth hormone receptors in avian epiphyseal growth-plate chondrocytes. Gen Comp Endocrinol 92, 179-88.
  59. Pines, M., Monsonego, E., Shalom-Barak, T., Halevy, O., and Hurwitz, S. (1993). Effect of hormones and growth factors on cell proliferation and synthesis of extracellular protein by epiphyseal growth-plate chondrocytes. Avian Endocrinology Ed. P.J. Sharp 249-260.