My lab studies how changes in the nutritional environment dictate cellular and organ adaptation, with a focus on beta cells. Specifically, we dissect the metabolic and functional heterogeneity of beta cells in sensing and responding to nutrients and how metabolic stress during aging and diabetes affects beta cell function. In addition, using human stem cell-derived beta cells we conduct high-throughput chemical and metabolic approaches to determine key regulators of human beta cell function Read more about Dr. Aharon Helman
Peer reviewed articles
- Sharabi, K., Hurwitz, A., Simon, A.J., Beitel, G.J., Morimoto, R.I., Rechavi, G., Sznajder, J.I., and Gruenbaum, Y. (2009a). Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proc Natl Acad Sci U S A 106, 4024-4029.
2001-2004 – B.Sc. in life sciences, The Hebrew University of Jerusalem. Amirim student, Graduated Cum Laude.
2005-2007 – M.Sc. in genetics. The Department of Genetics, The Hebrew University of Jerusalem. Advisor: Prof. Yosef Gruenbaum.
2007-2012 – Ph.D in genetics. The Department of Genetics, The Hebrew University of Jerusalem. Advisor: Prof. Yosef Gruenbaum.Read more >
Metabolic syndrome diseases, including diabetes, have become a world-wide epidemic affecting millions throughout the world. Dysregulated whole-body energy homeostasis is a hallmark of the metabolic syndrome, and better understanding of the molecular pathways that become dysregulated during its progression can ultimately lead to the development of new and improved therapies. Our goal is to understand how changes in nutritional and hormonal cues control basic metabolic pathways to modulate whole-body energy homeostasis.Read more >