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Application of Algebraic Topology to Homologous Recombination of DNA | Biochemistry, Food Science and Nutrition

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Head of Institute: Prof. Ido Braslavsky

Administrative manager: Rakefet Kalev

Office Address:
Institute of Biochemistry, Food Science and Nutrition,
Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem, 
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Application of Algebraic Topology to Homologous Recombination of DNA

Citation:

Braslavsky, I. ; Stavans, J. . Application Of Algebraic Topology To Homologous Recombination Of Dna. iScience 2018, 4, 64 - 67.

Date Published:

2018

Abstract:

SummaryBrouwer's fixed point theorem, a fundamental theorem in algebraic topology proved more than a hundred years ago, states that given any continuous map from a closed, simply connected set into itself, there is a point that is mapped unto itself. Here we point out the connection between a one-dimensional application of Brouwer's fixed point theorem and a mechanism proposed to explain how extension of single-stranded DNA substrates by recombinases of the RecA superfamily facilitates significantly the search for homologous sequences on long chromosomes.

Publisher's Version

Last updated on 07/11/2019