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A novel nonosteocytic regulatory mechanism of bone modeling


Ofer, L. ; Dean, M. N. ; Zaslansky, P. ; Kult, S. ; Shwartz, Y. ; Zaretsky, J. ; Griess-Fishheimer, S. ; Monsonego-Ornan, E. ; Zelzer, E. ; Shahar, R. A novel nonosteocytic regulatory mechanism of bone modeling. PLOS Biology 2019, 17, e3000140 -.

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Bone’s ability to change its morphology in response to load is widely attributed to osteocytes. A study of fish shows that bone can respond to load even in the absence of osteocytes, using a molecular mechanism that is conserved across vertebrates, albeit with different cellular effectors.

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Last updated on 07/11/2019