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The Role of Matrix Metalloproteinase-2 and Metalloproteinase-9 in Embryonic Neural Crest Cells and Their Derivatives | Biochemistry, Food Science and Nutrition

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Head of Institute: Prof. Ido Braslavsky

Administrative manager: Rakefet Kalev

Office Address:
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Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem, 
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The Role of Matrix Metalloproteinase-2 and Metalloproteinase-9 in Embryonic Neural Crest Cells and Their Derivatives

Citation:

Kalev-Altman, R. ; Monsonego-Ornan, E. ; Sela-Donenfeld, D. . The Role Of Matrix Metalloproteinase-2 And Metalloproteinase-9 In Embryonic Neural Crest Cells And Their Derivatives. In Proteases in Physiology and Pathology; Chakraborti, S. ; Dhalla, N. S., Eds.; Springer Singapore: Singapore, 2017; pp. 27 - 48.

Abstract:

Neural crest cells (NCCs) are transient cell populations that are initially residing at the dorsal-most part of the neural tube of the developing vertebrate embryo. At well-defined time points, NCCs detach from the neural tube as they undergo epithelial-to-mesenchymal transition (EMT) and migrate in distinct pathways to their final destinations. There, this unique cell population differentiates into a great variety of cell types including bone and cartilage tissues of the head and face, connective tissue of the heart, skin melanocytes, adipocytes, enteric neurons, and most of the peripheral sensory neurons, glia, and Schwann cells. Matrix metalloproteinases (MMPs) are a large family of matrix-degrading enzymes, which are divided into several subfamilies according to their structure and substrate specificity. The gelatinases subfamily, which includes MMP-2 and MMP-9 solely, is the most investigated group. Both MMP-2 and MMP-9 were previously reported to be expressed in embryonic NCCs and to have a role in their EMT and migration processes. In this review we present the most recent data regarding the role of MMP-2 and MMP-9 in embryonic NCCs and in their various derivatives in later embryonic stages and in adults.

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