Turning off Bacillus cereus quorum sensing system with peptidic analogs | Biochemistry, Food Science and Nutrition

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Turning off Bacillus cereus quorum sensing system with peptidic analogs

Citation:

Yehuda, A. ; Slamti, L. ; Bochnik-Tamir, R. ; Malach, E. ; Lereclus, D. ; Hayouka, Z. . Turning Off Bacillus Cereus Quorum Sensing System With Peptidic Analogs. Chemical Communications 2018, 54, 9777 - 9780.

Date Published:

2018

Abstract:

We explored quenching of the PlcR–PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

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