Citation:
Yehuda, A. ; Slamti, L. ; Bochnik-Tamir, R. ; Malach, E. ; Lereclus, D. ; Hayouka, Z. . Turning Off Bacillus Cereus Quorum Sensing System With Peptidic Analogs. Chemical Communications 2018, 54, 9777 - 9780.
Date Published:
2018Abstract:
We explored quenching of the PlcR–PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.